DM Testresults - Page 9

mijke · 11-03-2011, 02:26

The type of inheritance is not yet known. Most of researchers think it is multi factorial. And in all kind of research labs (of uni's and commercial)all over the world, they are still doing research for DM.

Al lot of specialist advises not to over react and not to exclude all carriers, but make crossings with Free dogs.

It depends of the gene pool (genetic diversity) of a breed how many years it will cost to reduce a genetic problem in a breed. And also how breed clubs and breeders can cooperate to reduce a problem in future.

Because you will have to work together to keep the genetic diversity also in future as large as possible! And it will cost years to reduce a problem.

It is of not any use to exclude carriers on this moment, especial because the type of inheritance is not known!
When we would exclude N/DM dogs for breeding the genetic diversity would become very small and more new genetic problems will appear!

So don't make a very big issue of DM, but test as much as possible and register how it is spread in the breed. And don't only use combinations Free x Free!!! Because that will also destroy a breed in time.

For example in Irish setter breed they did make a special program of registering CLAD (carrier x carrier was discouraged but carrier x Free was permitted and all litters had to be tested en registered for years ) and during a lot of years they did reduce the problem but did keep the genetic diversity.

DM is not the only problem in our breed! There are more factors you have to care of in breeding. And don't only look at test results or splendid exterior.. but also take care for a wide gene pool!

I was at a lecture of prof. Peelman (genetic specialist) and for example he did tell the audience: in all breeds where are a lot of the same ancestors, in future more gene mutations will appear.
On this moment 500 gene mutations in dog breeds are known and documented. And only of about 300 the type of inheritance is yet known. And just like all other specialists he did advice: The most important thing to keep in mind is: take care for as much as possible genetic diversity in a breed!

wera · 14-03-2011, 20:02

Chogan von Keschla

Degenerative Myelopathie - PCR
Myelopathie:
Ergebnis: Genotyp: N/N

Chagall von Keschla

Degenerative Myelopathie - PCR
Myelopathie:
Ergebnis: Genotyp: N/N

SARKA · 15-03-2011, 10:26

Arimminum Yuma
Degenerative Myelopathie - PCR
Myelopathie:
Ergebnis: Genotyp: N/N

wera · 16-03-2011, 10:44

Chenoa von Keschla
Degenerative Myelopathie - PCR
Myelopathie:
Ergebnis: Genotyp: N/N

*Satu · 18-03-2011, 17:31

Kennel Taabernakkelin DM results! More is comming...

Basior Jantarowa Wataha:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Baron spod Dumbiera:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype DM/DM

Wolfsirius Sleeping Storm:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Rocks'n Jewels Andradite:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype N/DM

Elys spod Dumbiera:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype N/DM

Ikala spod Dumbiera:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Finlandya de la Louve Blanche
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Hanka · 20-03-2011, 13:59

Hi Satu, I wish to Baron maximally health old age and I cross fingres DM will not be visible on him.

GalomyOak · 20-03-2011, 16:38

Quote:

Originally Posted by Hanka

Hi Satu, I wish to Baron maximally health old age and I cross fingres DM will not be visible on him.

Absolutely! As always, it's very nice to see openness from a breeder in sharing ALL health results publically, especially for an older dog who has had such a big modern influence in our breed. It means a lot - thank you!!! Big hugs to our Finnish pack!

draggar · 20-03-2011, 22:29

Yes, it is good to see the openness that kennels are having with this and we should see if the affected dogs do develop symptoms and when.

Some studies here believe that diet has a lot to do with it - GSDs that had diets that consisted of foods that had fats listed in the first 4 ingredients had a much higher chance of developing symptoms.

I also agree with Mijke - while DM isn't the best thing to have in your lines it is extremely easily managed and can be bred out of lines in as little as two generations. The concentration should be more on important issues like hips, elbows, and eyes as well as keeping an eye out for other possible factors.

mijke · 20-03-2011, 22:31

Thanks again Satu for sharing open ALL your test results!

Vaiva · 20-03-2011, 22:53

Quote:

Originally Posted by mijke

Thanks again Satu for sharing open ALL your test results!

Really - this is great when people do not hide the results that may seem "not so nice". It is a pitty many still think it is some kind of shame or what

We should maybe talk more about it - that DM/DM does not mean any tragedy

doublewolf · 21-03-2011, 19:46

From Italy:
BEY' CHEE DOZZ DE LA MOLLYNIERE DE LO SCALE
DM TEST GENOTYPE N/N

Lorry - MLS · 22-03-2011, 11:50

Dheer'Syb Ooh de la Mollynière de Lo'Scale : N/DM

Thalia Crying Wolf : DM/DM

*Satu · 22-03-2011, 11:50

Quote:

Originally Posted by Vaiva

that DM/DM does not mean any tragedy

Yes. This is not a big tragedy. In this moment puppies whit Baron all is only Carrier.
And Baron/ Elys all tested dogs are carrier.

I´m waiting for a more older dogs have DM results and breeders who have many litters in year make tests very soon.

Hanka · 22-03-2011, 12:01

Hi Lorry, I wish to Thalia maximally health life. I hope DM will not be visible on her too.

Lorry - MLS · 22-03-2011, 12:25

Quote:

Originally Posted by Hanka

Hi Lorry, I wish to Thalia maximally health life. I hope DM will not be visible on her too.

Merci de ces quelques mots de soutien Hanka ....ça me touche ...

Thalia, vient d'avoir 5 ans en Février dernier, elle est en pleine forme et j'espère qu'elle le restera encore longtemps ....

Lorry - MLS · 22-03-2011, 12:37

Thalianounette ....

Backman · 22-03-2011, 18:43

DM results from kennel Forever Wolf !

Blazy de la Louve Blanche
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/DM

Dream Wolf de la Louve Blanche
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/DM

Forever Wolf Arctic Hero
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Forever Wolf Arctic Angel
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Crying Wolf Luka
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/DM

Mikael · 22-03-2011, 19:44

Quote:

Originally Posted by *Satu

Kennel Taabernakkelin DM results! More is comming...

Basior Jantarowa Wataha:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Baron spod Dumbiera:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype DM/DM

Wolfsirius Sleeping Storm:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Rocks'n Jewels Andradite:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype N/DM

Elys spod Dumbiera:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype N/DM

Ikala spod Dumbiera:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Finlandya de la Louve Blanche
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Thanks for testing and sharing Satu

Very best regards / Mikael

z Peronówki · 23-03-2011, 10:20

Quote:

Originally Posted by Hanka

Hi Lorry, I wish to Thalia maximally health life. I hope DM will not be visible on her too.

Hanka, now a serious question - do you know PERSONALLY at least ONE Wolfdog who has any VISIBLE problems with DM?

I know some Wolfdogs which are moving really horrible but they are N/N....

Hanka · 23-03-2011, 11:17

I never had seen (on my own eyes) wolfdog with visible problems because DM.
Why you ask ?

11-03-2011, 02:26	#161
mijke Senior Member Join Date: Sep 2003 Location: Warnsveld Posts: 2,033	The type of inheritance is not yet known. Most of researchers think it is multi factorial. And in all kind of research labs (of uni's and commercial)all over the world, they are still doing research for DM. Al lot of specialist advises not to over react and not to exclude all carriers, but make crossings with Free dogs. It depends of the gene pool (genetic diversity) of a breed how many years it will cost to reduce a genetic problem in a breed. And also how breed clubs and breeders can cooperate to reduce a problem in future. Because you will have to work together to keep the genetic diversity also in future as large as possible! And it will cost years to reduce a problem. It is of not any use to exclude carriers on this moment, especial because the type of inheritance is not known! When we would exclude N/DM dogs for breeding the genetic diversity would become very small and more new genetic problems will appear! So don't make a very big issue of DM, but test as much as possible and register how it is spread in the breed. And don't only use combinations Free x Free!!! Because that will also destroy a breed in time. For example in Irish setter breed they did make a special program of registering CLAD (carrier x carrier was discouraged but carrier x Free was permitted and all litters had to be tested en registered for years ) and during a lot of years they did reduce the problem but did keep the genetic diversity. DM is not the only problem in our breed! There are more factors you have to care of in breeding. And don't only look at test results or splendid exterior.. but also take care for a wide gene pool! I was at a lecture of prof. Peelman (genetic specialist) and for example he did tell the audience: in all breeds where are a lot of the same ancestors, in future more gene mutations will appear. On this moment 500 gene mutations in dog breeds are known and documented. And only of about 300 the type of inheritance is yet known. And just like all other specialists he did advice: The most important thing to keep in mind is: take care for as much as possible genetic diversity in a breed! __________________ Vriendelijke groeten, Mijke PS: I am not a moderator anymore!!

14-03-2011, 20:02	#162
wera Junior Member Join Date: Nov 2003 Location: schmerikon Posts: 298	Chogan von Keschla Degenerative Myelopathie - PCR Myelopathie: Ergebnis: Genotyp: N/N Chagall von Keschla Degenerative Myelopathie - PCR Myelopathie: Ergebnis: Genotyp: N/N __________________ Hunde kommen, wenn sie gerufen werden. TWH`S nehmen die Mitteilung zur Kenntnis und kommen gelegentlich darauf zurück...

15-03-2011, 10:26	#163
SARKA Arimminum Kennel Join Date: Sep 2003 Location: Rimini Posts: 1,230	Arimminum Yuma Degenerative Myelopathie - PCR Myelopathie: Ergebnis: Genotyp: N/N __________________ Sarka Matrasova www.lupocecoslovacco.it

16-03-2011, 10:44	#164
wera Junior Member Join Date: Nov 2003 Location: schmerikon Posts: 298	Chenoa von Keschla Degenerative Myelopathie - PCR Myelopathie: Ergebnis: Genotyp: N/N __________________ Hunde kommen, wenn sie gerufen werden. TWH`S nehmen die Mitteilung zur Kenntnis und kommen gelegentlich darauf zurück...

18-03-2011, 17:31	#165
*Satu Junior Member Join Date: Aug 2004 Posts: 194	Kennel Taabernakkelin DM results! More is comming... Basior Jantarowa Wataha: Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N Baron spod Dumbiera: Degenerative Myelopathy - PCR Result Myelopathy Result: genotype DM/DM Wolfsirius Sleeping Storm: Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N Rocks'n Jewels Andradite: Degenerative Myelopathy - PCR Result Myelopathy Result: genotype N/DM Elys spod Dumbiera: Degenerative Myelopathy - PCR Result Myelopathy Result: genotype N/DM Ikala spod Dumbiera: Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N Finlandya de la Louve Blanche Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N __________________ www.csv.fi

20-03-2011, 13:59	#166
Hanka Senior Member Join Date: Nov 2003 Location: Kadaň Posts: 1,622	Hi Satu, I wish to Baron maximally health old age and I cross fingres DM will not be visible on him.

20-03-2011, 22:29	#168
draggar Junior Member Join Date: Feb 2010 Location: New Hampshire Posts: 370	Yes, it is good to see the openness that kennels are having with this and we should see if the affected dogs do develop symptoms and when. Some studies here believe that diet has a lot to do with it - GSDs that had diets that consisted of foods that had fats listed in the first 4 ingredients had a much higher chance of developing symptoms. I also agree with Mijke - while DM isn't the best thing to have in your lines it is extremely easily managed and can be bred out of lines in as little as two generations. The concentration should be more on important issues like hips, elbows, and eyes as well as keeping an eye out for other possible factors. __________________ Fred Lanting's Official Site Dog Actors

20-03-2011, 22:31	#169
mijke Senior Member Join Date: Sep 2003 Location: Warnsveld Posts: 2,033	Thanks again Satu for sharing open ALL your test results! __________________ Vriendelijke groeten, Mijke PS: I am not a moderator anymore!!

21-03-2011, 19:46	#171
doublewolf doublewolf Join Date: Nov 2005 Location: Favria-TO Posts: 121	From Italy: BEY' CHEE DOZZ DE LA MOLLYNIERE DE LO SCALE DM TEST GENOTYPE N/N __________________ Silvana, Walter e Farah e Fenics e Sweety e .....Best Baloo e.... i felini di casa

22-03-2011, 11:50	#172
Lorry - MLS Member Join Date: Mar 2006 Posts: 988	Dheer'Syb Ooh de la Mollynière de Lo'Scale : N/DM Thalia Crying Wolf : DM/DM

22-03-2011, 12:01	#174
Hanka Senior Member Join Date: Nov 2003 Location: Kadaň Posts: 1,622	Hi Lorry, I wish to Thalia maximally health life. I hope DM will not be visible on her too.

22-03-2011, 18:43	#177
Backman Junior Member Join Date: Feb 2007 Location: Finland Posts: 22	DM results from kennel Forever Wolf ! Blazy de la Louve Blanche Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/DM Dream Wolf de la Louve Blanche Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/DM Forever Wolf Arctic Hero Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N Forever Wolf Arctic Angel Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N Crying Wolf Luka Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/DM

23-03-2011, 11:17	#180
Hanka Senior Member Join Date: Nov 2003 Location: Kadaň Posts: 1,622	I never had seen (on my own eyes) wolfdog with visible problems because DM. Why you ask ?

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