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Old 09-04-2009, 14:52   #1
mijke
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Default Pituitary Dwarfism test for CsW is available!

The university of Utrecht did validate the pituitary dwarfism test for the CsW breed

And since April 2009 it also possible to test a CsW for pituitary dwarfism!

Unfortunately also in CsW breed several dwarfs (from several lines) are known.

And when 1% is dwarf in a population, 18 % will be carrier of this mutated gen!
And the number of carriers in practice is often much higher than thought




But as of now there is no need that more CsW dwarfs will be born!

Because of a simple test can be established if a dog is carrier of this mutated gene.

And not any dog has to be out of breeding program when he/she is carrier.
The only thing is not to make any crossings between carrier x carrier!(of this mutated gen)


Therefore it makes sense to test as much as possible CsW's to see how this mutation in the breed is spread.
And to prevent another CsW dwarf will be ever born, you have to test all CsW's that will be used for breeding!




How an owner can test his CsW for pituitary dwarfism:

Because not all vets will know the test, it can be useful to give them a copy of the article of dr. H. Kooistra en drs. A. Voorbij: Pituitary dwarfism in German shepherd dogs and Saarloos wolfhounds -Availability of a genetic test-
Here you can download this document as pdf file **


A form blood sample is here to download as pdf file ** .

** A pdf file is to open with program Acrobat Reader. You can download this program for free for example Here
  • The owner can fill in all the info about himself and the dog in the form: ”Blood DNA research Pituitary Dwarfism” and sign it.
  • Then the owner can go to his own veterinarian with his CsW, the form the pedigree and a copy of the pedigree.
  • The vet has to check the chip number, fill in the info and has to sign the form.
  • Then he can collect 4ml EDTA blood sample.
The 4 ml blood sample (collected in an EDTA containing tube) can together with the signed form and the copy of the pedigree send by the veterinarian to:

Dr. H.S. Kooistra
Department of Clinical Sciences of Companion Animals
Faculty of Veterinary Medicine, Utrecht University
Yalelaan 108
3584 CM Utrecht
The Netherlands



  • After the test the university will send a bill to the owner
  • The costs of this genetic test is Euro 100 (excl. VAT).
  • When the university has received the paying of the owner, they will send him the test result.
  • When the dog is free of dwarfism gen, the owner also receives an official certificate.

Here some general info about pituitary dwarfism:



What is pituitary dwarfism:
Dwarfism is a horrible incurable disorder which you don’t wish to any dog. A dwarf has a badly developed pituitary , which means that certain hormones (such as growth hormones) are not produced. Due to the shortage of the production of the thyroid stimulating hormone, they have a slow functioning thyroid. Besides the fact that these dogs stay small, they are also haunted by various horrible side effects (e.g. baldness, itching, inflammations, malfunctioning of the liver and kidneys, slow behaviour) when they are not treated with medicines on a daily basis.



Recognising and existence of dwarfism in a breed:
Dwarfism is not always recognised by a breeder!!
Many dwarfs die in the uterus or die during the birth.
And moreover 90% of the living born dwarfs die in the first week.
Pups behind in growth are often not recognised as dwarfs. After (4 weeks or later) people see that a pup is different in comparison with the other pups. Dwarfism is known in the breeds German Shepherd, Karelische Bearsdog, Saarlooswolfhond and the Czechoslovakian Wolfdog.

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Old 09-04-2009, 15:08   #2
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The CsV breed and future puppies thanks you for your EXCELLENT WORK !!!

Very best regards / Mikael & Hronec
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Old 09-04-2009, 15:34   #3
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Well done Mijke.
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Old 09-04-2009, 16:36   #4
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Thanks a lot for your effort Mijke

I will test both of my dogs soon...

Greetings Rolf
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Old 10-05-2009, 00:06   #5
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Last update May 2009:

8 CsW’s were already tested (7 from Holland and 1 of Belgium)

From these CsW’s are 6 free of this gen mutation.

And 2 are carrier of dwarfism gen. One of them is from Dutch breeding line and the other was imported from CZ.

When I have received the copy’s of this results, I’ll publish all the info (with names of the dogs)
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Old 10-05-2009, 04:29   #6
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Scary...

But very good that there is a test now...Thanks for all of the work and updates, Mijke...

Marcy
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Old 10-05-2009, 09:53   #7
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Sorry but I have a problem with adding photos

Last edited by DanielZ; 10-05-2009 at 10:42.
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Old 10-05-2009, 13:43   #8
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Daniel, are you sure it is dwarf puppy? Because this type of coat is normal coat of adult dog. Can it be only hybrid?

Please if somebody know about more pups, write info to Mijke. She can make "map" of this mutation in population. It is very interest and we want find "first wolfdog" which was carier of this.
I am sure, it must be in population more than we know now.

Nobody will write names of parents,pups with it, if will not be agreement from owner.
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Old 10-05-2009, 15:51   #9
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Quote:
Originally Posted by Hanka View Post
Daniel, are you sure it is dwarf puppy? Because this type of coat is normal coat of adult dog. Can it be only hybrid?

Please if somebody know about more pups, write info to Mijke. She can make "map" of this mutation in population. It is very interest and we want find "first wolfdog" which was carier of this.
I am sure, it must be in population more than we know now.

Nobody will write names of parents,pups with it, if will not be agreement from owner.

It is a dwarf German Shepherd .In German Shepherd sometimes born dwarf. They live about 4-5 years. In


In the Polish "A friend of Dog" a few years ago was an article on dwarf dogs.
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Old 10-05-2009, 23:19   #10
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there are a few different types of dwarfism in the dog. The pituitary is one type and for this type there is a test for now.

this dig doesn't look like a pituitary type of dwarf for me. But maybe this dog did get some supplements of the missing hormoons?? For the GSD this test was validated a little while ago so was this dog tested?

For me this dog has a fairly normal coat (on the picture) , it almost has the shape of a dashund as if his long bones didn't grow enough, but on the other had it has a kined of a foxy head, so it can be a pituirary dwarf but it also could have an other cause.
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Old 10-05-2009, 23:29   #11
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on the dutch forum there is a topic called
Uitslagen DNA test hypofysaire dwerggroei = Results from the DNA test

in this topic there wil be only names of the tested dogs with the results

VRIJ = Free of the mutation
Drager = Carier of the mutation

So everybody can check that topic to see and find out the results from the tested dogs.

SO THAT TOPIC IS NO PLACE FOR DISCUSSIONS!!
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Old 24-07-2009, 15:31   #12
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I just got DNA-results from University of Utrecht and both Uno and Xtreme are free of the mutated gene that causes Pituitary Dwarfism



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Old 25-07-2009, 00:57   #13
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Congratulations to everybody whit good results

How many dogs has been tested this far and can one say anything yet about how common the Dwarf gene is on the CsV breed ???

Or will there be a statistic report about the Dwarf gene, when enough data is collected ???

Very best regards / Mikael
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Old 25-07-2009, 01:44   #14
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Quote:
Originally Posted by Mikael View Post
How many dogs has been tested this far and can one say anything yet about how common the Dwarf gene is on the CsV breed ???
Take a look here : http://www.wolfdog-healthinfo.org/pageID_7976969.html

I guess the results of my dogs will be uploaded as soon as Mijke have time

Greetings Rolf

Last edited by Juniorwolf; 25-07-2009 at 01:46. Reason: wrong link
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Old 27-07-2009, 20:29   #15
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Quote:
Originally Posted by rolf View Post
Take a look here : http://www.wolfdog-healthinfo.org/pageID_7976969.html

I guess the results of my dogs will be uploaded as soon as Mijke have time

Greetings Rolf
Thanks

Best regards / Mikael
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Old 05-08-2009, 16:34   #16
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Thanks Rolf!
The test results of your dogs will be visible at the Wolfdog health site at the end of this week

Beside your dogs were also 11 in Holland registered CsW’s tested. This owners did use the blood sample form of the Dutch CsW club.
And on this form is that the results will be send to the secretariat of the club for publishing.
So I did wait a while for these results of the club, but till today I did not receive anything

I also did hear of the university that several people did not agree with publishing the info of the test results!
So the info was only send to the owners.

So the tests of these owners are worthless for the CsW breed!!
It is very, very sad and stupid, that there are owners who are making (expensive tests) and keep the results secret.

I hope in future the dwarfism test will be accepted and obligated by kennel organisations. So the results of this test will come, just like HD results, on the pedigree of offspring!
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Old 09-12-2009, 21:31   #17
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I saw the "actualization" at the nederland forum that we have already 30 dgs tested with the results published.
The results are very interessing for the breeders and I'm sure some people want to test his dogs for this, but the main problem seems to be... the price is too high for some people.
So I was wondering about, if we get one ammount of owners (upper than the actual number of tested dogs) willing to make this test in his dogs, would have the possibility of the university turn the price of the test lower?
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Old 09-12-2009, 21:47   #18
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maybe they are willing to make a discount when you can give them 50 or more samples at one time?

Maybe Mijke can ask them, she is the one with the connections

But what do you think about the fact that there are 6 of the 30 dogs carriers of this gen?
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Old 09-12-2009, 21:58   #19
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Quote:
Originally Posted by jmvdwiel View Post
maybe they are willing to make a discount when you can give them 50 or more samples at one time?

Maybe Mijke can ask them, she is the one with the connections

But what do you think about the fact that there are 6 of the 30 dogs carriers of this gen?
Was exactly the results which makes me worrie about the breed situation for this disease and ask about one possible discount.
I found the number of carriers too high for so few dogs tested, in a breed with small genetic pool like CzW its can means more serious problems than we tought.
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Old 09-12-2009, 23:29   #20
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There were 30 CsW’s tested for Pituitary Dwarfism.
Of these 30 CsW’s were 6 carriers of the mutated gen.


On the site wolfdog-healthinfo.org you can find the test results. Click HERE

Because 1/5 of the tested dogs was carrier, it is very useful to test more CsW’s!
Only then we can see how this disease is spread in the population

And it is entirely useful for breeders to test for breeding!
And especial when you want to breed with offspring, brother/ sisters, parents and ancestors of carriers of dwarfism gen.

But even when a male or female is carrier, it is no problem to breed with them!

Not any carrier has to excluded for breeding!

Only don’t make combinations of carrier x carrier!

On top of this topic you can find how an owner can test a CsW for Pituitary Dwarfism.
And you also can find there a link for the blood sample form.
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