Results from Laboklin for Wolfy von Konigs-Terry

Degenerative Myelopathy N/DM
Malignant Hyperthermia N/N

We are waiting for the Dwarfism results

News from Italy. Test Degenerative Myelopathy
Cosmo Daniel Elite Farah: N/N
Cosmo Daniel Elite Fenics: N/N
Di' Sweety de la mollyniere de lo' Scale: N/N

Breeder Paraj Auta
Di' Samadu de la mollyniere de lo' Scale: N/N
CKAA' LOUP MAH de la mollyniere de lo' Scale: N/N
DHEER SYB de la mollyniere de lo' scale: N/N
Giasone Olimpalus: N/N

Hello,

really nice to hear, but what about their litter mates.
Are they all N/N as well? It would be interesting to know.

Michael

ARIMMINUM ZIBIBBO

Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N = esente

Mother Naboo is N/N.Father H'Gensis Borte Tchino is ? ,but his parents Ambra and Jerry Lee are N/N.

Hi Micha
We are'nt breader but... we know very well this race. We test the DM over the our twins Farah & Fenics (8 year olds). This test is made because they have many suns and nepewh.
On the last Farah's litter, we know at this moment the results of 3 daughters. (Di Sweety MLS, Di Samadù MLS, Di Sunshine MLS): alls N/N.
About Fenics, the last coupled was with Deer Sib MLS both are N/N and their generate 7 puppies (6 female & 1 male born the november 2, 2010).
We stongly hope that the new puppie's owners want to do a DM test.
About Giasone Olimpalus, we hope that you are happy to know that his father come from your kennel:o

Sincerely

I am very happy Sylvana !
Merci à toi et à Daniela d'avoir fait le nécessaire ....
Heureuse également pour les chiots de Fenics et Dheer'Sybb, qui du coup, sont forcément N/N !
C'est vraiment super pour Daniela de démarrer sur des bases saines pour sa 1ère portée de CLTS à son affixe !
Tellement contente pour elle .....

Ciao Silvana,

I was just curious to see the results of the whole litters.
That would be interesting for once.
Of course I know where Giasone comes from;-)...

Michael

Another interesting part from publication Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis

"Mode of Inheritance of DM. All of the strictly diagnosed DMaffected
dogs were A/A homozygotes; however, several of the
aged A/A homozygotes were symptom free. Thus, DM appears
to be an incompletely penetrant autosomal recessive disease,
whereas most human SOD1 mutations cause dominant forms of
ALS. However, the N90A SOD1 isoform is associated with a
recessively inherited form of ALS in some families, but with a
dominant form in others (29, 30). The natural history of the
disease in the families with recessive inheritance resembles
canine DM in that onset is invariably in the lower limbs followed
by a slow disease progression, whereas the sites of onset and the
rates of progression of ALS in heterozygous N90A patients are
much more variable (29, 30). Among the families segregating for
the dominant form of ALS, rare patients with 2 copies of the
mutant SOD1 allele had much earlier ages at disease onset than
patients inheriting only a single copy (31, 32). Also, hSOD1m
mice with higher transgene copy numbers exhibit earlier disease
onset (5, 33), and the disease also occurs much earlier in
homozygous hSOD1m mice than in the corresponding heterozygotes
(34). With DM, the intermediate levels of staining for
SOD1 inclusions observed in 2 of the 5 aged heterozygotes (Fig.
3 E and F) suggests that pathological processes are underway in
these dogs even though no clinical signs are apparent. The
pathology in SOD1:c.118GA heterozygotes may develop too
slowly to become clinically apparent within the usual canine life
span. In this case, only A/A homozygotes would exhibit clinical
signs and the mode of inheritance would appear to be recessive
even if the pathogenesis, like that of ALS, involves a toxic gain
of function."

In addition, hypothesis dogs (N/DM) might be developping the disease (commonly much later, and more rare cases), so unfortunately we are still far to understand.

It practically says that in Dogs the gene seems to be recessive because in heterozygotes dogs the developing of the disease is so slow it does not appear in the natural lifespan? As in Human Beings the same type of mutation is dominant?
I sincerely hope we'll have more and more data on this illness as it is all a bit confusing... sigh...

Ckaa'Loup-Bah de la Mollynière de Lo'Scale : N /DM

Chye Z' Ddey de la Mollynière de Lo'Scale : N/DM

Sa mère : Cynthia Spod Dumbiera : N/N
Son père : Crying Wolf Rambo : N/DM

aslan vom sturmwind : N/DM

Hello,
this is news of August 2010, but I want to insert also here:

VOICE OF WOLF

Degenerative Myelopathie - PCR
Myelopathie
Ergebnis: Genotyp N/DM


ASHOKA

Degenerative Myelopathie - PCR
Myelopathie
Ergebnis: Genotyp N/N

re
 

Results from Italy

GOJA OLIM PALUS
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype N/N


GRADISCA OLIM PALUS
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype N/DM

Results from France : z Orel Ochrana kennel

We knew neither father nor mother DM test results (mother not made) before making the covering, so we decided to test all the litter.

First complete litter tested before leaving kennel :

VOICE OF WOLF z mou es X CKAA'LOUP-BAH de la Mollynière de Lo'Scale

Males (3) :

Chip n° 250269201042514 N/N

Chip n° 250269201042016 N/DM

Chip n° 250269201040297 DM/DM

Females (5) :

Chip n° 250269201038637 N/N

Chip n° 250269201042639 N/DM

Chip n° 250269201039646 N/DM

Chip n° 250269201044803 N/DM

Chip n° 250269201044525 N/DM

Dogs name will be revealed when i receive DM test certificates.

All purchasers are and will be informed about their duty and the consequences of these tests.

Results from France

Ar'wan de la Mollynière de Lo'Scale : N/DM

I really commend you for your honesty with being public with results, and informing the purchasers of your puppies of their status! It's something many of us have faced as breeders; I did not know the DM results of my dogs either when I bred them, and tested afterwards. I really agree with being open and honest and not "hiding" results, good or bad - that is the kind of breeder I like to be - and I will recommend to other people!

Sherdor,

is very a good thing indeed to have made test your range and to make the results public, cheer!!! sincerely, cheer !!!

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on the other hand, sorry but I mouse slightly, I reconsider with your remark made little time ago advising me to stop breeding of CSW having had an enormous problem in my range, my small reached nanism….

I dare to hope that your point of view to be changed... :rock_3

Did you also test the parents?

... Yes ... (but i didn't know this disease exists before making the covering...)

Voice of Wolf test has been made in August 2010 (as repeated by Riccardo, see above).

Ckaa'loup-bah (the mother) has been made in january 2011 (see above Lorry Leclerc message)