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mijke · 26-01-2010, 16:59

An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.

An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding theoretically 50 percent of the offspring will receive the disease allele. Carriers will not become ill.

An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected dogs will become ill.

I am convinced that it is only a matter of time, that all diseases that we now can see in GSD and SWH breed will appear in CsW.

But because we now have DNA tests for Dwarfism and DM we also can find out how these diseases are spread in the breed.

In the dwarfism mutation we see it is more spread (in several lines) then thought.
In DM we know now only the official results of 2 CsW's (from different lines) who were affected. And I am sure there are a lot more.
But because this disease appears when the dog is older, it is not always recognized (by owner or vet) as DM.

So at least it would be a good reason for owners of older dogs with these kind of problems to make the DNA test!
But also for all owners and breeders it is a good suggestion to test , to see if and how this mutation is spread.

But of course this is always a personal choice!

As I did said before, in all labs that make the DNA test for DM can be made a test for a CsW. Because now we know the mutation in SOD1-Gen is the same for CsW breed.

For example in: van Haeringen lab in Holland

By sending EDTA blood or swab with a form to:

Dr. van Haeringen lab . BV
P.O. Box 408
6700 AK Wageningen
The Netherlands

HERE you can find their info about the DM test in English language
HERE you can download a form in English language

The price is Euro 59,50 ex BTW
An owner receives a bill together with the test result

Or in: Laboklin labor in Germany

By sending EDTA blood or swab with a form to:

Laboklin Labor
Postbox 1810
97668 Bad Kissingen
Deutschland

HERE you can find their info about the DM test in German language.

HERE you can find their info about the DM test in English language

HERE you can download a form and the info about this in German language

HERE you can download a form and the info about this in English language

26-01-2010, 16:59	#5
mijke Senior Member Join Date: Sep 2003 Location: Warnsveld Posts: 2,033	An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population. An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding theoretically 50 percent of the offspring will receive the disease allele. Carriers will not become ill. An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected dogs will become ill. I am convinced that it is only a matter of time, that all diseases that we now can see in GSD and SWH breed will appear in CsW. But because we now have DNA tests for Dwarfism and DM we also can find out how these diseases are spread in the breed. In the dwarfism mutation we see it is more spread (in several lines) then thought. In DM we know now only the official results of 2 CsW's (from different lines) who were affected. And I am sure there are a lot more. But because this disease appears when the dog is older, it is not always recognized (by owner or vet) as DM. So at least it would be a good reason for owners of older dogs with these kind of problems to make the DNA test! But also for all owners and breeders it is a good suggestion to test , to see if and how this mutation is spread. But of course this is always a personal choice! As I did said before, in all labs that make the DNA test for DM can be made a test for a CsW. Because now we know the mutation in SOD1-Gen is the same for CsW breed. For example in: van Haeringen lab in Holland By sending EDTA blood or swab with a form to: Dr. van Haeringen lab . BV P.O. Box 408 6700 AK Wageningen The Netherlands HERE you can find their info about the DM test in English language HERE you can download a form in English language The price is Euro 59,50 ex BTW An owner receives a bill together with the test result Or in: Laboklin labor in Germany By sending EDTA blood or swab with a form to: Laboklin Labor Postbox 1810 97668 Bad Kissingen Deutschland HERE you can find their info about the DM test in German language. HERE you can find their info about the DM test in English language HERE you can download a form and the info about this in German language HERE you can download a form and the info about this in English language __________________ Vriendelijke groeten, Mijke PS: I am not a moderator anymore!!