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jmvdwiel · 21-02-2010, 15:28

http://www.k-9cart.com/Pet-Wheelchai...eelchairs.html

I stole a little bit of text from this site and supplemented it with my own

All dogs carry two copies of the SOD1 gene. The genetic testing results will tell you if the mutation is present and if so whether one or both genes is involved. Possible results:
· Normal/Normal (N/N): Both genes are normal and do NOT carry the defect in the SOD1 gene. In the seven dog breeds that the University of Missouri has extensively studied, no dog that has two normal genes has ever had a confirmed diagnosis of DM. If used in a dog breeding program, N/N dogs will pass the normal gene onto the puppies. Thus, the puppies should be free of DM also.
· Abnomal/Normal (A/N): This dog has one normal and one abnormal gene and is called a "carrier." Carrier dogs in the seven breeds studied by the University of Missouri have never had a confirmed case of DM. However, as a carrier, this dog could transfer the abnormal gene to the puppies.
· Abnormal/Abnormal (A/A): This dog has two abnormal copies of the SOD1 gene and is at risk for developing DM. All dogs that have had confirmed cases of DM that were tested by the University of Missouri in their study also had two abnormal genes. However, not all dogs that will test positive (A/A) and be at risk will show signs of DM. In part, this is because DM is a disease of middle to old age. So younger at risk dogs may not look normal and not show signs until much older. Some of the at risk dogs may never reach an old enough age to show signs. But all dogs that are A/A will pass on one copy of the genetic defect to their puppies.

SORRY BUT ALL THE DOTS SHOULD BE OPEN SPACES BUT THAT DIDN"T WORK

Possible crossings:
NN X NN Male and female have two normal genes: male: N and N female NN
.....N.......N
N ..NN...NN
N...NN...NN so all normal dogs

NN X AN or AN X NN Male or female has to normal genes and the other one is a Carrier
.....A.....N
N..AN...NN
N..AN...NN so half is AN (carier) and half is NN (normal)

NA X NA male and female are cariers
........N.......A
N.....NN....NA
A.....NA....AA , so 1/4 NN (normal) , 1/2 NA (carier), and 1/4 AA(affected)

AA X AN or AN X AA Male or female has 2 Affected genes and the other one is a carier
.....A.....A
A ..AA..AA
N...AN..AN so half AA (affected) and half AN (carier)

AA X NN or NN X AA Male or female is affeced and th other one is Normal
.....A....A
N...NA...NA
N...NA...NA so al wil be cariers and not sick

AA x AA Male and female have two affected genes
.....A....A
A..AA ..AA
A ..AA ..AA so all dog wil be AA (affected)

21-02-2010, 15:28	#17
jmvdwiel Senior Member Join Date: Apr 2007 Posts: 1,061	http://www.k-9cart.com/Pet-Wheelchai...eelchairs.html I stole a little bit of text from this site and supplemented it with my own All dogs carry two copies of the SOD1 gene. The genetic testing results will tell you if the mutation is present and if so whether one or both genes is involved. Possible results: · Normal/Normal (N/N): Both genes are normal and do NOT carry the defect in the SOD1 gene. In the seven dog breeds that the University of Missouri has extensively studied, no dog that has two normal genes has ever had a confirmed diagnosis of DM. If used in a dog breeding program, N/N dogs will pass the normal gene onto the puppies. Thus, the puppies should be free of DM also. · Abnomal/Normal (A/N): This dog has one normal and one abnormal gene and is called a "carrier." Carrier dogs in the seven breeds studied by the University of Missouri have never had a confirmed case of DM. However, as a carrier, this dog could transfer the abnormal gene to the puppies. · Abnormal/Abnormal (A/A): This dog has two abnormal copies of the SOD1 gene and is at risk for developing DM. All dogs that have had confirmed cases of DM that were tested by the University of Missouri in their study also had two abnormal genes. However, not all dogs that will test positive (A/A) and be at risk will show signs of DM. In part, this is because DM is a disease of middle to old age. So younger at risk dogs may not look normal and not show signs until much older. Some of the at risk dogs may never reach an old enough age to show signs. But all dogs that are A/A will pass on one copy of the genetic defect to their puppies. SORRY BUT ALL THE DOTS SHOULD BE OPEN SPACES BUT THAT DIDN"T WORK Possible crossings: NN X NN Male and female have two normal genes: male: N and N female NN .....N.......N N ..NN...NN N...NN...NN so all normal dogs NN X AN or AN X NN Male or female has to normal genes and the other one is a Carrier .....A.....N N..AN...NN N..AN...NN so half is AN (carier) and half is NN (normal) NA X NA male and female are cariers ........N.......A N.....NN....NA A.....NA....AA , so 1/4 NN (normal) , 1/2 NA (carier), and 1/4 AA(affected) AA X AN or AN X AA Male or female has 2 Affected genes and the other one is a carier .....A.....A A ..AA..AA N...AN..AN so half AA (affected) and half AN (carier) AA X NN or NN X AA Male or female is affeced and th other one is Normal .....A....A N...NA...NA N...NA...NA so al wil be cariers and not sick AA x AA Male and female have two affected genes .....A....A A..AA ..AA A ..AA ..AA so all dog wil be AA (affected) Last edited by jmvdwiel; 21-02-2010 at 19:07.