Quote:
Originally Posted by saschia
Hladat v tom Saarloosy je samozrejme najjednoduchsie a najrealistickejsie. Ovsem, teoreticky, ak by mal Fallko Kollarov dvor jeden z genov TYRP1 poskodeny (a mutacie sa deju pravidelne), tak by toto sfarbenie v tomto spojeni mohlo vzniknut... Co som len tak narychlo mrkla o charakteristike bb sfarbenia u psov, jedna sa o niekolko roznych mutacii, ktore aj v kombinacii sposobuju hnede (v zmysle hnedy pigment namiesto cierneho, hnedy nos a sliznice), hlbsie som sa zatial nedostala (pristup k clankom z domu nemam), ale z toho mi zatial vyplyva obycajna strata funkcie daneho proteinu, ktora lahko nastava aj de novo mutaciami.
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An interesting part in the paper, the fact that the authors did not consider for "Grackle" case a de novo mutation possibility could show their thinking about the time scale of those kind of mutation is not so short:
"It is not sur-prising that the recessive brown could be maintained in
black dogs for many generations. Grackle, who carries one copy of
the proline deletion in TYRP1 (Table 3), was black and white,
and her closest brown German Longhair ancestor is six gen-
erations back."