DM test for CsW is available!

[draggar]

Let me look into it. I might have a contact in UFl in Ganesville, or have a contact who has a contact there.

[jmvdwiel]

http://www.k-9cart.com/Pet-Wheelchai...eelchairs.html

I stole a little bit of text from this site and supplemented it with my own

All dogs carry two copies of the SOD1 gene. The genetic testing results will tell you if the mutation is present and if so whether one or both genes is involved. Possible results:
· Normal/Normal (N/N): Both genes are normal and do NOT carry the defect in the SOD1 gene. In the seven dog breeds that the University of Missouri has extensively studied, no dog that has two normal genes has ever had a confirmed diagnosis of DM. If used in a dog breeding program, N/N dogs will pass the normal gene onto the puppies. Thus, the puppies should be free of DM also.
· Abnomal/Normal (A/N): This dog has one normal and one abnormal gene and is called a "carrier." Carrier dogs in the seven breeds studied by the University of Missouri have never had a confirmed case of DM. However, as a carrier, this dog could transfer the abnormal gene to the puppies.
· Abnormal/Abnormal (A/A): This dog has two abnormal copies of the SOD1 gene and is at risk for developing DM. All dogs that have had confirmed cases of DM that were tested by the University of Missouri in their study also had two abnormal genes. However, not all dogs that will test positive (A/A) and be at risk will show signs of DM. In part, this is because DM is a disease of middle to old age. So younger at risk dogs may not look normal and not show signs until much older. Some of the at risk dogs may never reach an old enough age to show signs. But all dogs that are A/A will pass on one copy of the genetic defect to their puppies.

SORRY BUT ALL THE DOTS SHOULD BE OPEN SPACES BUT THAT DIDN"T WORK

Possible crossings:
NN X NN Male and female have two normal genes: male: N and N female NN
.....N.......N
N ..NN...NN
N...NN...NN so all normal dogs

NN X AN or AN X NN Male or female has to normal genes and the other one is a Carrier
.....A.....N
N..AN...NN
N..AN...NN so half is AN (carier) and half is NN (normal)


NA X NA male and female are cariers
........N.......A
N.....NN....NA
A.....NA....AA , so 1/4 NN (normal) , 1/2 NA (carier), and 1/4 AA(affected)

AA X AN or AN X AA Male or female has 2 Affected genes and the other one is a carier
.....A.....A
A ..AA..AA
N...AN..AN so half AA (affected) and half AN (carier)


AA X NN or NN X AA Male or female is affeced and th other one is Normal
.....A....A
N...NA...NA
N...NA...NA so al wil be cariers and not sick

AA x AA Male and female have two affected genes
.....A....A
A..AA ..AA
A ..AA ..AA so all dog wil be AA (affected)

[draggar]

Fred got back to me with "Here's my latest with DM" (and asked me to put it on his site):
http://www.fredlanting.org/2010/02/t...athy%E2%80%9D/

While I didn't see the article go into the actual genetics, your way (jmvdwiel) makes more sense (my way would have had the disease elimiated naturally unless there was either very bad luck or far more A/A dogs than believed).

Still - this means an A/A lines could have the DM "bred out" in two generations.

A/A to an N/N - All "carriers"
N/A to another N/A - half carriers, half not carriers (no DM).

It's sad that so many GSD breeders refuse to test for DM but claim "it's not in my lines!" (yet how do you know if you don't test?). Any dog that we consider to breed to Kiri has to be DM tested.

Originally Posted by GalomyOak

Thanks Mijke!

On my next pay check, I will test at least a couple of dogs, and then the other two on the paycheck after that. The Missouri test is better for another reason - in the US (or anywhere), the results are displayed on the OFA database, along with all of our dog's other information (except for PennHip results - hopefully UPenn will have an online database someday). The cost for this test is US$65.

Marcy

Did you test Luna's parents? What were the results?

$65 is well worth the test.

[jmvdwiel]

NA x NA gives 1/4 NN (normal dogs), 1/2 NA (cariers) and 1/4 AA (affected dogs)!!!!, SO 3/4 healthy dogs but 1/4 sick dogs !!!

NA if you want to eliminate the gen should be crossed with NN, but this might be an utopia, but time/money and the effort of the breeders wil say wat is going to happen

Sorry I did forget this one in my former post (shame on me )

[quote=draggar;281016]
A/A to an N/N - All "carriers"
N/A to another N/A - half carriers, half not carriers (no DM).

quote]

[GalomyOak]

Originally Posted by draggar

Did you test Luna's parents? What were the results?

$65 is well worth the test.

The test (or rather, it's validity for the CSV) came out after the litter was on the ground. But, as stated before, next paycheck, the test will be done.

Marcy

[draggar]

I'm sure Sara will do the test also. Better to have each generation checked in case any mutations popped up.

[loco]

The first testresult of DM that is made public .

Is from Hogan Sky van Hagia Sophia.
http://www.wolfdog.org/forum/showthread.php?t=13872
He is carrier of the mutated gene .
But he does not get's DM .

The second testresult of DM that is made public .

Is from Chumani from bandit's world.
http://www.wolfdog.org/forum/showthr...95510&langid=1
She is carrier of the mutated gene .
But she does not get's DM .

Thank you both for making this public .
Groette Martine.

[draggar]

Just make sure anyone you breed Hogan and Chumani to does not have the mutated gene and you're fine.

I'm sure with some careful breeding we can cut DM down in the breed significantly.