DM Testresults

mijke · 11-03-2011, 02:26

The type of inheritance is not yet known. Most of researchers think it is multi factorial. And in all kind of research labs (of uni's and commercial)all over the world, they are still doing research for DM.

Al lot of specialist advises not to over react and not to exclude all carriers, but make crossings with Free dogs.

It depends of the gene pool (genetic diversity) of a breed how many years it will cost to reduce a genetic problem in a breed. And also how breed clubs and breeders can cooperate to reduce a problem in future.

Because you will have to work together to keep the genetic diversity also in future as large as possible! And it will cost years to reduce a problem.

It is of not any use to exclude carriers on this moment, especial because the type of inheritance is not known!
When we would exclude N/DM dogs for breeding the genetic diversity would become very small and more new genetic problems will appear!

So don't make a very big issue of DM, but test as much as possible and register how it is spread in the breed. And don't only use combinations Free x Free!!! Because that will also destroy a breed in time.

For example in Irish setter breed they did make a special program of registering CLAD (carrier x carrier was discouraged but carrier x Free was permitted and all litters had to be tested en registered for years ) and during a lot of years they did reduce the problem but did keep the genetic diversity.

DM is not the only problem in our breed! There are more factors you have to care of in breeding. And don't only look at test results or splendid exterior.. but also take care for a wide gene pool!

I was at a lecture of prof. Peelman (genetic specialist) and for example he did tell the audience: in all breeds where are a lot of the same ancestors, in future more gene mutations will appear.
On this moment 500 gene mutations in dog breeds are known and documented. And only of about 300 the type of inheritance is yet known. And just like all other specialists he did advice: The most important thing to keep in mind is: take care for as much as possible genetic diversity in a breed!

11-03-2011, 02:26	#11
mijke Senior Member Join Date: Sep 2003 Location: Warnsveld Posts: 2,033	The type of inheritance is not yet known. Most of researchers think it is multi factorial. And in all kind of research labs (of uni's and commercial)all over the world, they are still doing research for DM. Al lot of specialist advises not to over react and not to exclude all carriers, but make crossings with Free dogs. It depends of the gene pool (genetic diversity) of a breed how many years it will cost to reduce a genetic problem in a breed. And also how breed clubs and breeders can cooperate to reduce a problem in future. Because you will have to work together to keep the genetic diversity also in future as large as possible! And it will cost years to reduce a problem. It is of not any use to exclude carriers on this moment, especial because the type of inheritance is not known! When we would exclude N/DM dogs for breeding the genetic diversity would become very small and more new genetic problems will appear! So don't make a very big issue of DM, but test as much as possible and register how it is spread in the breed. And don't only use combinations Free x Free!!! Because that will also destroy a breed in time. For example in Irish setter breed they did make a special program of registering CLAD (carrier x carrier was discouraged but carrier x Free was permitted and all litters had to be tested en registered for years ) and during a lot of years they did reduce the problem but did keep the genetic diversity. DM is not the only problem in our breed! There are more factors you have to care of in breeding. And don't only look at test results or splendid exterior.. but also take care for a wide gene pool! I was at a lecture of prof. Peelman (genetic specialist) and for example he did tell the audience: in all breeds where are a lot of the same ancestors, in future more gene mutations will appear. On this moment 500 gene mutations in dog breeds are known and documented. And only of about 300 the type of inheritance is yet known. And just like all other specialists he did advice: The most important thing to keep in mind is: take care for as much as possible genetic diversity in a breed! __________________ Vriendelijke groeten, Mijke PS: I am not a moderator anymore!!