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Health and nutrition How to feed a Wolfdog, information about dog food, how to vaccinate and what to do if the dog gets ill.... |
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26-01-2011, 16:46 | #121 |
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Results from Laboklin for Wolfy von Konigs-Terry
Degenerative Myelopathy N/DM Malignant Hyperthermia N/N We are waiting for the Dwarfism results |
26-01-2011, 23:26 | #122 |
doublewolf
Join Date: Nov 2005
Location: Favria-TO
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News from Italy. Test Degenerative Myelopathy
Cosmo Daniel Elite Farah: N/N Cosmo Daniel Elite Fenics: N/N Di' Sweety de la mollyniere de lo' Scale: N/N Breeder Paraj Auta Di' Samadu de la mollyniere de lo' Scale: N/N CKAA' LOUP MAH de la mollyniere de lo' Scale: N/N DHEER SYB de la mollyniere de lo' scale: N/N Giasone Olimpalus: N/N
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Silvana, Walter e Farah e Fenics e Sweety e .....Best Baloo e.... i felini di casa |
27-01-2011, 16:04 | #123 |
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Hello,
really nice to hear, but what about their litter mates. Are they all N/N as well? It would be interesting to know. Michael |
27-01-2011, 18:18 | #124 |
Arimminum Kennel
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27-01-2011, 22:52 | #125 | |
doublewolf
Join Date: Nov 2005
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Quote:
We are'nt breader but... we know very well this race. We test the DM over the our twins Farah & Fenics (8 year olds). This test is made because they have many suns and nepewh. On the last Farah's litter, we know at this moment the results of 3 daughters. (Di Sweety MLS, Di Samadù MLS, Di Sunshine MLS): alls N/N. About Fenics, the last coupled was with Deer Sib MLS both are N/N and their generate 7 puppies (6 female & 1 male born the november 2, 2010). We stongly hope that the new puppie's owners want to do a DM test. About Giasone Olimpalus, we hope that you are happy to know that his father come from your kennel Sincerely
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Silvana, Walter e Farah e Fenics e Sweety e .....Best Baloo e.... i felini di casa |
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28-01-2011, 00:50 | #126 | |
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Quote:
Merci à toi et à Daniela d'avoir fait le nécessaire .... Heureuse également pour les chiots de Fenics et Dheer'Sybb, qui du coup, sont forcément N/N ! C'est vraiment super pour Daniela de démarrer sur des bases saines pour sa 1ère portée de CLTS à son affixe ! Tellement contente pour elle ..... Last edited by Lorry - MLS; 28-01-2011 at 11:15. |
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28-01-2011, 10:31 | #127 |
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Ciao Silvana,
I was just curious to see the results of the whole litters. That would be interesting for once. Of course I know where Giasone comes from... Michael |
28-01-2011, 13:00 | #128 | |
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Quote:
"Mode of Inheritance of DM. All of the strictly diagnosed DMaffected dogs were A/A homozygotes; however, several of the aged A/A homozygotes were symptom free. Thus, DM appears to be an incompletely penetrant autosomal recessive disease, whereas most human SOD1 mutations cause dominant forms of ALS. However, the N90A SOD1 isoform is associated with a recessively inherited form of ALS in some families, but with a dominant form in others (29, 30). The natural history of the disease in the families with recessive inheritance resembles canine DM in that onset is invariably in the lower limbs followed by a slow disease progression, whereas the sites of onset and the rates of progression of ALS in heterozygous N90A patients are much more variable (29, 30). Among the families segregating for the dominant form of ALS, rare patients with 2 copies of the mutant SOD1 allele had much earlier ages at disease onset than patients inheriting only a single copy (31, 32). Also, hSOD1m mice with higher transgene copy numbers exhibit earlier disease onset (5, 33), and the disease also occurs much earlier in homozygous hSOD1m mice than in the corresponding heterozygotes (34). With DM, the intermediate levels of staining for SOD1 inclusions observed in 2 of the 5 aged heterozygotes (Fig. 3 E and F) suggests that pathological processes are underway in these dogs even though no clinical signs are apparent. The pathology in SOD1:c.118GA heterozygotes may develop too slowly to become clinically apparent within the usual canine life span. In this case, only A/A homozygotes would exhibit clinical signs and the mode of inheritance would appear to be recessive even if the pathogenesis, like that of ALS, involves a toxic gain of function." In addition, hypothesis dogs (N/DM) might be developping the disease (commonly much later, and more rare cases), so unfortunately we are still far to understand.
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http://www.amicale-chien-loup-tcheco...m/csvstat.html Last edited by elf; 28-01-2011 at 13:04. |
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28-01-2011, 13:10 | #129 |
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It practically says that in Dogs the gene seems to be recessive because in heterozygotes dogs the developing of the disease is so slow it does not appear in the natural lifespan? As in Human Beings the same type of mutation is dominant?
I sincerely hope we'll have more and more data on this illness as it is all a bit confusing... sigh... |
03-02-2011, 17:05 | #130 |
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Ckaa'Loup-Bah de la Mollynière de Lo'Scale : N /DM
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10-02-2011, 22:05 | #131 |
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Chye Z' Ddey de la Mollynière de Lo'Scale : N/DM
Sa mère : Cynthia Spod Dumbiera : N/N Son père : Crying Wolf Rambo : N/DM |
11-02-2011, 00:24 | #132 |
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aslan vom sturmwind : N/DM
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16-02-2011, 17:42 | #133 |
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Hello,
this is news of August 2010, but I want to insert also here: VOICE OF WOLF Degenerative Myelopathie - PCR Myelopathie Ergebnis: Genotyp N/DM ASHOKA Degenerative Myelopathie - PCR Myelopathie Ergebnis: Genotyp N/N |
21-02-2011, 21:39 | #134 |
OLIM PALUS KENNEL
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Location: Latina
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re
Results from Italy
GOJA OLIM PALUS Degenerative Myelopathy - PCR Result Myelopathy Result: genotype N/N GRADISCA OLIM PALUS Degenerative Myelopathy - PCR Result Myelopathy Result: genotype N/DM |
23-02-2011, 22:59 | #135 |
Senior Member
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Results from France : z Orel Ochrana kennel
We knew neither father nor mother DM test results (mother not made) before making the covering, so we decided to test all the litter. First complete litter tested before leaving kennel : VOICE OF WOLF z mou es X CKAA'LOUP-BAH de la Mollynière de Lo'Scale Males (3) : Chip n° 250269201042514 N/N Chip n° 250269201042016 N/DM Chip n° 250269201040297 DM/DM Females (5) : Chip n° 250269201038637 N/N Chip n° 250269201042639 N/DM Chip n° 250269201039646 N/DM Chip n° 250269201044803 N/DM Chip n° 250269201044525 N/DM Dogs name will be revealed when i receive DM test certificates. All purchasers are and will be informed about their duty and the consequences of these tests.
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www.ochrana.fr |
23-02-2011, 23:00 | #136 |
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Results from France
Ar'wan de la Mollynière de Lo'Scale : N/DM
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23-02-2011, 23:16 | #137 | |
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Quote:
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"What lies behind us and what lies ahead of us are tiny matters compared to what lies within us."~Henry David Thoreau http://www.galomyoak.com |
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24-02-2011, 00:30 | #138 |
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Sherdor,
is very a good thing indeed to have made test your range and to make the results public, cheer!!! sincerely, cheer !!! ------------------------------------------------------------------ on the other hand, sorry but I mouse slightly, I reconsider with your remark made little time ago advising me to stop breeding of CSW having had an enormous problem in my range, my small reached nanism…. I dare to hope that your point of view to be changed... |
24-02-2011, 17:05 | #139 | |
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Did you also test the parents?
Quote:
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24-02-2011, 19:00 | #140 |
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... Yes ... (but i didn't know this disease exists before making the covering...)
Voice of Wolf test has been made in August 2010 (as repeated by Riccardo, see above). Ckaa'loup-bah (the mother) has been made in january 2011 (see above Lorry Leclerc message)
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