Health results (also DM!!) in the Wolfdog.org database

[saschia]

Originally Posted by mijke

MDR1= Multi Drug Resistance

Well, I can imagine multi-drug resistance in cancer cells and in bacteria, but in dogs???

Malignant hypertermia - is there a valid test? As far as I know, malignant hyperthermia is caused by mutations on RyR1 gene... If it behaves similarly to RyR2 gene, than any testing is quite a lot of work, as there are more than 50 different RyR2 mutations (causing CPVT) in people identified so far, in 3 different regions of the gene, and RyR1 as well as RyR2 are huge genes. Or is it identified by encountering the problem and subsequent muscle biopsy?

[Nebulosa]

Originally Posted by saschia

Well, I can imagine multi-drug resistance in cancer cells and in bacteria, but in dogs???

The same protein encoded by this gene is associate with the blood-brain barrier, this protein is responsible to pump some toxines out of the brain, this defect turns some drugs like Ivermectine letal to these dogs.

[yukidomari]

Originally Posted by saschia

Well, I can imagine multi-drug resistance in cancer cells and in bacteria, but in dogs???

Unfortunately Australian Shepherds are in my experience the breed with the highest incidence of MDR1 mutation. Chemicals commonly found in heartworm preventatives can be dangerous when applied on dogs with MDR1 mutations (along with other chemicals). Lots of Aussie owners we know purposely stay away from medications with Ivermectin in it, even if they have not tested the specific dogs for MDR1 mutation.

[saschia]

Thanks for clearing up. So it is not resistance, but sensitivity, actually... Very interesting...

[michaelundinaeichhorn]

Is there any known wolfdog that has shown MH or MDR1 mutation? I know that this can occure in GSH but never heard of a wolfdog.