DM Testresults

Teshi · 01-03-2011, 10:35

Exor von der Wolfsranch

Degenerative Myelopathie - PCR
Myelopathie:
Ergebnis: Genotyp: N/N

SARKA · 03-03-2011, 15:50

ARIMMINUM NOUAU

Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

04-03-2011, 11:55

Arimminum Olcan

Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Lorry - MLS · 08-03-2011, 11:01

E' de la Mollynière de Lo'Scale : N/DM

Conan von Keschla : N/DM

Ezechielelupo · 10-03-2011, 21:13

EZECHIELE OLIM PALUS

Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/DM

Lorry - MLS · 10-03-2011, 23:05

Ckoo'Mah-Akk de la Mollynière de Lo'Scale : N/DM

Il en ressort pour l'instant que, sur 6 chiens testés, issus du même père, une seule femelle est N/N .....
On est bien loin du taux de transmission évalué à 50 % !

Enid Black · 10-03-2011, 23:51

I can read French but I cannot write it, so please pardon me

.

The 50% possibility of transmission is on every puppy. It means that it is like throwing a coin in the air and seeing if it exits a face or the other. Every throw has 50% for each face BUT it does not depend on the other throws. On 10 throws, you could have 3 face ONE and 7 face TWO, it does not mean that the probability is 30/70, it is 50/50 but every launch is independent. The same goes for the puppies... I hope I have been clear enough ^^.

mijke · 11-03-2011, 02:26

The type of inheritance is not yet known. Most of researchers think it is multi factorial. And in all kind of research labs (of uni's and commercial)all over the world, they are still doing research for DM.

Al lot of specialist advises not to over react and not to exclude all carriers, but make crossings with Free dogs.

It depends of the gene pool (genetic diversity) of a breed how many years it will cost to reduce a genetic problem in a breed. And also how breed clubs and breeders can cooperate to reduce a problem in future.

Because you will have to work together to keep the genetic diversity also in future as large as possible! And it will cost years to reduce a problem.

It is of not any use to exclude carriers on this moment, especial because the type of inheritance is not known!
When we would exclude N/DM dogs for breeding the genetic diversity would become very small and more new genetic problems will appear!

So don't make a very big issue of DM, but test as much as possible and register how it is spread in the breed. And don't only use combinations Free x Free!!! Because that will also destroy a breed in time.

For example in Irish setter breed they did make a special program of registering CLAD (carrier x carrier was discouraged but carrier x Free was permitted and all litters had to be tested en registered for years ) and during a lot of years they did reduce the problem but did keep the genetic diversity.

DM is not the only problem in our breed! There are more factors you have to care of in breeding. And don't only look at test results or splendid exterior.. but also take care for a wide gene pool!

I was at a lecture of prof. Peelman (genetic specialist) and for example he did tell the audience: in all breeds where are a lot of the same ancestors, in future more gene mutations will appear.
On this moment 500 gene mutations in dog breeds are known and documented. And only of about 300 the type of inheritance is yet known. And just like all other specialists he did advice: The most important thing to keep in mind is: take care for as much as possible genetic diversity in a breed!

01-03-2011, 10:35	#1
Teshi Mutti Join Date: Jul 2006 Location: NRW Posts: 181	Exor von der Wolfsranch Degenerative Myelopathie - PCR Myelopathie: Ergebnis: Genotyp: N/N __________________ Neid muss man sich erarbeiten, Mitleid bekommt man geschenkt.

03-03-2011, 15:50	#2
SARKA Arimminum Kennel Join Date: Sep 2003 Location: Rimini Posts: 1,230	ARIMMINUM NOUAU Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N __________________ Sarka Matrasova www.lupocecoslovacco.it

10-03-2011, 23:51	#7
Enid Black Senior Member Join Date: Jan 2010 Location: Arezzo Posts: 1,142	I can read French but I cannot write it, so please pardon me . The 50% possibility of transmission is on every puppy. It means that it is like throwing a coin in the air and seeing if it exits a face or the other. Every throw has 50% for each face BUT it does not depend on the other throws. On 10 throws, you could have 3 face ONE and 7 face TWO, it does not mean that the probability is 30/70, it is 50/50 but every launch is independent. The same goes for the puppies... I hope I have been clear enough ^^. __________________ Enid Black, Gianni, Spettro and Kira

11-03-2011, 02:26	#8
mijke Senior Member Join Date: Sep 2003 Location: Warnsveld Posts: 2,033	The type of inheritance is not yet known. Most of researchers think it is multi factorial. And in all kind of research labs (of uni's and commercial)all over the world, they are still doing research for DM. Al lot of specialist advises not to over react and not to exclude all carriers, but make crossings with Free dogs. It depends of the gene pool (genetic diversity) of a breed how many years it will cost to reduce a genetic problem in a breed. And also how breed clubs and breeders can cooperate to reduce a problem in future. Because you will have to work together to keep the genetic diversity also in future as large as possible! And it will cost years to reduce a problem. It is of not any use to exclude carriers on this moment, especial because the type of inheritance is not known! When we would exclude N/DM dogs for breeding the genetic diversity would become very small and more new genetic problems will appear! So don't make a very big issue of DM, but test as much as possible and register how it is spread in the breed. And don't only use combinations Free x Free!!! Because that will also destroy a breed in time. For example in Irish setter breed they did make a special program of registering CLAD (carrier x carrier was discouraged but carrier x Free was permitted and all litters had to be tested en registered for years ) and during a lot of years they did reduce the problem but did keep the genetic diversity. DM is not the only problem in our breed! There are more factors you have to care of in breeding. And don't only look at test results or splendid exterior.. but also take care for a wide gene pool! I was at a lecture of prof. Peelman (genetic specialist) and for example he did tell the audience: in all breeds where are a lot of the same ancestors, in future more gene mutations will appear. On this moment 500 gene mutations in dog breeds are known and documented. And only of about 300 the type of inheritance is yet known. And just like all other specialists he did advice: The most important thing to keep in mind is: take care for as much as possible genetic diversity in a breed! __________________ Vriendelijke groeten, Mijke PS: I am not a moderator anymore!!

04-03-2011, 11:55	#3
maya Guest Posts: n/a	Arimminum Olcan Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N

08-03-2011, 11:01	#4
Lorry - MLS Member Join Date: Mar 2006 Posts: 988	E' de la Mollynière de Lo'Scale : N/DM Conan von Keschla : N/DM

10-03-2011, 21:13	#5
Ezechielelupo Junior Member Join Date: Jan 2008 Posts: 258	EZECHIELE OLIM PALUS Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/DM

10-03-2011, 23:05	#6
Lorry - MLS Member Join Date: Mar 2006 Posts: 988	Ckoo'Mah-Akk de la Mollynière de Lo'Scale : N/DM Il en ressort pour l'instant que, sur 6 chiens testés, issus du même père, une seule femelle est N/N ..... On est bien loin du taux de transmission évalué à 50 % !