DM Testresults

Enid Black · 10-03-2011, 23:51

I can read French but I cannot write it, so please pardon me

.

The 50% possibility of transmission is on every puppy. It means that it is like throwing a coin in the air and seeing if it exits a face or the other. Every throw has 50% for each face BUT it does not depend on the other throws. On 10 throws, you could have 3 face ONE and 7 face TWO, it does not mean that the probability is 30/70, it is 50/50 but every launch is independent. The same goes for the puppies... I hope I have been clear enough ^^.

mijke · 11-03-2011, 02:26

The type of inheritance is not yet known. Most of researchers think it is multi factorial. And in all kind of research labs (of uni's and commercial)all over the world, they are still doing research for DM.

Al lot of specialist advises not to over react and not to exclude all carriers, but make crossings with Free dogs.

It depends of the gene pool (genetic diversity) of a breed how many years it will cost to reduce a genetic problem in a breed. And also how breed clubs and breeders can cooperate to reduce a problem in future.

Because you will have to work together to keep the genetic diversity also in future as large as possible! And it will cost years to reduce a problem.

It is of not any use to exclude carriers on this moment, especial because the type of inheritance is not known!
When we would exclude N/DM dogs for breeding the genetic diversity would become very small and more new genetic problems will appear!

So don't make a very big issue of DM, but test as much as possible and register how it is spread in the breed. And don't only use combinations Free x Free!!! Because that will also destroy a breed in time.

For example in Irish setter breed they did make a special program of registering CLAD (carrier x carrier was discouraged but carrier x Free was permitted and all litters had to be tested en registered for years ) and during a lot of years they did reduce the problem but did keep the genetic diversity.

DM is not the only problem in our breed! There are more factors you have to care of in breeding. And don't only look at test results or splendid exterior.. but also take care for a wide gene pool!

I was at a lecture of prof. Peelman (genetic specialist) and for example he did tell the audience: in all breeds where are a lot of the same ancestors, in future more gene mutations will appear.
On this moment 500 gene mutations in dog breeds are known and documented. And only of about 300 the type of inheritance is yet known. And just like all other specialists he did advice: The most important thing to keep in mind is: take care for as much as possible genetic diversity in a breed!

wera · 14-03-2011, 20:02

Chogan von Keschla

Degenerative Myelopathie - PCR
Myelopathie:
Ergebnis: Genotyp: N/N

Chagall von Keschla

Degenerative Myelopathie - PCR
Myelopathie:
Ergebnis: Genotyp: N/N

SARKA · 15-03-2011, 10:26

Arimminum Yuma
Degenerative Myelopathie - PCR
Myelopathie:
Ergebnis: Genotyp: N/N

wera · 16-03-2011, 10:44

Chenoa von Keschla
Degenerative Myelopathie - PCR
Myelopathie:
Ergebnis: Genotyp: N/N

*Satu · 18-03-2011, 17:31

Kennel Taabernakkelin DM results! More is comming...

Basior Jantarowa Wataha:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Baron spod Dumbiera:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype DM/DM

Wolfsirius Sleeping Storm:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Rocks'n Jewels Andradite:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype N/DM

Elys spod Dumbiera:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype N/DM

Ikala spod Dumbiera:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Finlandya de la Louve Blanche
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Hanka · 20-03-2011, 13:59

Hi Satu, I wish to Baron maximally health old age and I cross fingres DM will not be visible on him.

Mikael · 22-03-2011, 19:44

Quote:

Originally Posted by *Satu

Kennel Taabernakkelin DM results! More is comming...

Basior Jantarowa Wataha:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Baron spod Dumbiera:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype DM/DM

Wolfsirius Sleeping Storm:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Rocks'n Jewels Andradite:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype N/DM

Elys spod Dumbiera:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: genotype N/DM

Ikala spod Dumbiera:
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Finlandya de la Louve Blanche
Degenerative Myelopathy - PCR
Result Myelopathy
Result: Genotype: N/N

Thanks for testing and sharing Satu

Very best regards / Mikael

10-03-2011, 23:51	#1
Enid Black Senior Member Join Date: Jan 2010 Location: Arezzo Posts: 1,142	I can read French but I cannot write it, so please pardon me . The 50% possibility of transmission is on every puppy. It means that it is like throwing a coin in the air and seeing if it exits a face or the other. Every throw has 50% for each face BUT it does not depend on the other throws. On 10 throws, you could have 3 face ONE and 7 face TWO, it does not mean that the probability is 30/70, it is 50/50 but every launch is independent. The same goes for the puppies... I hope I have been clear enough ^^. __________________ Enid Black, Gianni, Spettro and Kira

11-03-2011, 02:26	#2
mijke Senior Member Join Date: Sep 2003 Location: Warnsveld Posts: 2,033	The type of inheritance is not yet known. Most of researchers think it is multi factorial. And in all kind of research labs (of uni's and commercial)all over the world, they are still doing research for DM. Al lot of specialist advises not to over react and not to exclude all carriers, but make crossings with Free dogs. It depends of the gene pool (genetic diversity) of a breed how many years it will cost to reduce a genetic problem in a breed. And also how breed clubs and breeders can cooperate to reduce a problem in future. Because you will have to work together to keep the genetic diversity also in future as large as possible! And it will cost years to reduce a problem. It is of not any use to exclude carriers on this moment, especial because the type of inheritance is not known! When we would exclude N/DM dogs for breeding the genetic diversity would become very small and more new genetic problems will appear! So don't make a very big issue of DM, but test as much as possible and register how it is spread in the breed. And don't only use combinations Free x Free!!! Because that will also destroy a breed in time. For example in Irish setter breed they did make a special program of registering CLAD (carrier x carrier was discouraged but carrier x Free was permitted and all litters had to be tested en registered for years ) and during a lot of years they did reduce the problem but did keep the genetic diversity. DM is not the only problem in our breed! There are more factors you have to care of in breeding. And don't only look at test results or splendid exterior.. but also take care for a wide gene pool! I was at a lecture of prof. Peelman (genetic specialist) and for example he did tell the audience: in all breeds where are a lot of the same ancestors, in future more gene mutations will appear. On this moment 500 gene mutations in dog breeds are known and documented. And only of about 300 the type of inheritance is yet known. And just like all other specialists he did advice: The most important thing to keep in mind is: take care for as much as possible genetic diversity in a breed! __________________ Vriendelijke groeten, Mijke PS: I am not a moderator anymore!!

14-03-2011, 20:02	#3
wera Junior Member Join Date: Nov 2003 Location: schmerikon Posts: 298	Chogan von Keschla Degenerative Myelopathie - PCR Myelopathie: Ergebnis: Genotyp: N/N Chagall von Keschla Degenerative Myelopathie - PCR Myelopathie: Ergebnis: Genotyp: N/N __________________ Hunde kommen, wenn sie gerufen werden. TWH`S nehmen die Mitteilung zur Kenntnis und kommen gelegentlich darauf zurück...

15-03-2011, 10:26	#4
SARKA Arimminum Kennel Join Date: Sep 2003 Location: Rimini Posts: 1,230	Arimminum Yuma Degenerative Myelopathie - PCR Myelopathie: Ergebnis: Genotyp: N/N __________________ Sarka Matrasova www.lupocecoslovacco.it

16-03-2011, 10:44	#5
wera Junior Member Join Date: Nov 2003 Location: schmerikon Posts: 298	Chenoa von Keschla Degenerative Myelopathie - PCR Myelopathie: Ergebnis: Genotyp: N/N __________________ Hunde kommen, wenn sie gerufen werden. TWH`S nehmen die Mitteilung zur Kenntnis und kommen gelegentlich darauf zurück...

18-03-2011, 17:31	#6
*Satu Junior Member Join Date: Aug 2004 Posts: 194	Kennel Taabernakkelin DM results! More is comming... Basior Jantarowa Wataha: Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N Baron spod Dumbiera: Degenerative Myelopathy - PCR Result Myelopathy Result: genotype DM/DM Wolfsirius Sleeping Storm: Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N Rocks'n Jewels Andradite: Degenerative Myelopathy - PCR Result Myelopathy Result: genotype N/DM Elys spod Dumbiera: Degenerative Myelopathy - PCR Result Myelopathy Result: genotype N/DM Ikala spod Dumbiera: Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N Finlandya de la Louve Blanche Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N __________________ www.csv.fi

20-03-2011, 13:59	#7
Hanka Senior Member Join Date: Nov 2003 Location: Kadaň Posts: 1,622	Hi Satu, I wish to Baron maximally health old age and I cross fingres DM will not be visible on him.