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Old 06-06-2011, 11:45   #11
elf
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Originally Posted by saschia View Post
OK, I am reading now the original papewr on the TYRP1 mutations causing bb phenotype, so more to come, but from what I understood untill now, they are loss-of-function kind of mutations, which actually can occur de novo, and with Fallko Kollarov dvor being common ancestor of both Thalia and Sibir, if he gained a new loss-of-function mutation of TYRP1, then it could show exactly like it happened here. Which doesn't mean it cannot be due to inmixing of Saarloos, but, if we are lucky, it can be looked into, by finding out what allele is present in the red pups, and compare it to allelle present in forrest/brown Saarloos wolfdogs.

Anyway, off to look at the paper (have access here at work).
An interesting part in the paper, the fact that the authors did not consider for "Grackle" case a de novo mutation possibility could show their thinking about the time scale of those kind of mutation is not so short:

"It is not sur-prising that the recessive brown could be maintained in
black dogs for many generations. Grackle, who carries one copy of
the proline deletion in TYRP1 (Table 3), was black and white,
and her closest brown German Longhair ancestor is six gen-
erations back."

Last edited by elf; 06-06-2011 at 11:52.
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