When a dwarf is born

[mijke]

On this moment only these DNA gene test are available for the CsW breed:

• Dwarfism
• DM (Degenerative Myolopathy)
• MH (Maligne Hyperthermie)

A lot of other DNA tests like for example MDR1 are not yet validated for the CsW breed.
Also several research labs in different countries are (for example) working on DNA tests for PRA, Epilepsy and HD.

More info about DM is to find on English forum in the topic about DM in my threads 1, 5 and 9

Movies that shows what is DM like are for example

This

or

THIS

or

THIS

In the past I did write something on the English forum about labs and DNA storage:
A lot of laboratories all over the world are working on several new tests for dog diseases.
Of course labs are commercial, so they are developing tests because there is a market for this.
For all the labs, dog owners and dog clubs are a very interesting group, because they have not real commercial /market goals.
Most of these labs are asking dog owners to send for free EDTA blood to do their investigations.
And when they have developed a test the same dog owners can pay a lot for this test!

Most of the labs (and university's!) are asking 4ml EDTA blood for a genetic test (or for developing a new test).
But to be honest they only need 1 mg to distillate DNA. And the rest of the blood sample they can use for other test of themselves.
So the most attractive deal for a lab is to receive hundreds of blood samples of the same breed of group!! (So I do understand the request of the lab that did ask for blood of 500 CsW's for HD DNA research!)

But groups of owners and breed clubs (who can collect a lot of samples for research purposes), can also negotiate with several labs!
They can offer them a lot of blood samples for free for research for a specific test. And in exchange for this, they can ask for a reduced price (for all owners who did cooperate) when this test is available.

All kind of labs have tests for different diseases. (there is not a lab who have all the tests for a breed) So they can make their own price for a test. Only sometimes there is a competition because they have developed the same test. (for an other breed there was a test for 250 dollar in US and now the same test in Europe is available for 90 euro )

That is why I am now also working at cooperation with a lab who did make good offer for storage EDTA blood for all CsW's. The owner of the dog remain also owner of the stored blood and can decide which test he wants to make. So an owners only has to send one time 4 ml EDTA blood and of the DNA distillations a lot of test can be made (in all the labs the owner wishes).
In a few weeks I will have all the info and can explain more.

[sciamalaia]

Dal momento che il Nanismo Ipofisario è un disordine recessivo di un singolo gene, la nascita di un esemplare malato indica che entrambe I genitori sono portatori del gene mutato.

[SARKA]

Ho parlato con il titolare della clinica e laboratori veterinari a Padova,l'unico centro in Italia per anticorpali e le altre analisi del sangue.
Visto che sarebbe interessato anche alla procedura del nanismo ipofisario (ovviamente ci deve essere un numero di clc discreto).
Comunque in ogni caso sarebbe disposto a fare uno screening gratuito per la razza , ma dobbiamo organizzarci a portare in 2-3 giorni 20-30 clc sani d'età da 2 a 6 anni.Sarebbe un campione delle analisi per la razza,visto che lo sta facendo anche per le altre razze.
Vorrei sapere se riusciamo a organizzarci.
Il dottore visto che la percentuale del nanismo è alta (6 su 30)mi ha detto è abbastanza preoccupante.
Fatemi sapere chi è interessato.

[SERENA]

Ma il brevetto per il nanismo ipofisario non era solo dell'università olandese per il momento?
Fammi capire, possono fare questo test?

[SARKA]

Non ancora ma perché i costi sono alti ,ma se riusciamo avere un numero di clc si informerà a Utrecht,infatti mi ha confermato che ci sono pochissimi centri al mondo.Intanto farebbe screening gratuito del sangue e dell'urina per monitorare la razza.

[sciamalaia]

Possiamo mandargli i campioni di sangue o dobbiamo presentarcci col cane a Padova?

[sciamalaia]

Inoltre Sarka, se hai bisogno che vada di persona a parlare con questo medico a Padova dimmi pure perchè tra me e l'Alice siamo li tutte le settimane.

[SARKA]

Originally Posted by sciamalaia

Possiamo mandargli i campioni di sangue o dobbiamo presentarcci col cane a Padova?

Dobbiamo presentarci col cane,almeno 20 in 2-3 giorni.
La clinica si chiama San Marco e il veterinario è Marco Caldin.

[mijke]

[QUOTE = SERENA; 280542e] Maar het octrooi voor hypofysaire dwerggroei was niet enige Nederlandse universiteit voor het moment?
Laat mij begrijpen, kan deze test? [/ QUOTE]

After years of research the Dutch university of Utrecht did discover this gene mutation. And they are now working on a scientific publication.
When this is ready they will sell the test to labs. And it depends of these labs what the price will be in future!

But because they did not want to lose time, in the meantime they test the breeds for who the test is validated.
It is a complicated test that costs a lot of time. That is why they always wait for more blood samples and test in one time. They have to do this besides their normal work and research that is why it is also a high price.

But till this moment there is not any other lab what can do the dwarfism test!

In other posts on wolfdog I did explain several times that any lab wants to have blood of a group for research!
I can give you a list of all kind of labs worldwide who wants to collect blood of breed groups
And yes it is very good when labs do research for breeds, but realize it is a commercial world!
When we send blood for Free, they can maybe develop a test for a disease. But when there is a test they can ask the same people a high price for this test!

So it is great when a lab in Italy wants to do research for a dwarfism test!
But when you send blood of a group of 20 -30 for this, you can negotiate about the price ( for all senders of blood) for a dwarfism test in future!!

Sarka ma 2-3 giorni vorrebbe dire lunedi o martedi , io non posso con cosi poco preavviso prendere ferie putroppo , tocca coinvolgere chi abita da quelle parti .

[SARKA]

Ma no,dobbiamo organizzarci per le date,importante andarci tutti insieme.

[Navarre]

Originally Posted by mijke

Movies that shows what is DM like are for example

or

or

Lo sapevo che non dovevo leggere questo thread, lo sapevo, lo sapevo, lo sapevo e invece no, porca zozza.

[mijke]

[QUOTE = Navarra; 280522e] Ik wist dat ik niet lees deze draad, wist ik, ik wist, ik wist het, maar nee, godverdomme. [/ QUOTE]


It is an awful disease.... And we also now know 2 CsW's who have for sure DM (proven by test)...
One of them is in very bad condition and will be euthanatized....